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TI: Estimating COVID-19 vaccine effectiveness against severe acute respiratory infections (SARI) hospitalisations associated with laboratory-confirmed SARS-CoV-2 : an evaluation using the test-negative design : guidance document PU: Copenhagen : World Health Organization, Regional Office for Europe, . 52 stran. LA: eng RT: monografie, knihy DE: Betacoronavirus ; COVID-19 ; epidemický výskyt choroby ; infekce ; vakcinace ; syndrom akutního respiračního selhání PT: publikace WHO AB: This guidance document outlines an approach to leverage existing surveillance systems for Severe Acute Respiratory Infection (SARI) to estimate COVID-19 vaccine effectiveness (VE) in preventing SARI associated with laboratory-confirmed SARS-CoV-2 using existing SARI surveillance systems. The approach uses the test-negative design to evaluate VE; cases are SARI patients who tested positive for SARS-CoV-2, and controls are SARI patients who tested negative for SARS-CoV-2.This document is intended to be used as a guidance document to support countries and institutions that are interested in conducting research on COVID-19 vaccine effectiveness in SARI patients. It outlines an approach to post-introduction COVID-19 vaccine effectiveness evaluation in SARI patients that complements existing WHO Unity Studies, which focus on sero-epidemiological investigations. Research should be conducted only after site-specific protocols are developed and approved by the relevant local ethical review committee(s). SG: NLK: online LI: https://www.who.int/publications/i/item/WHO-EURO-2021-2481-42237-58308 - plný text volně přístupný AN: MED00207597 DT: 210727