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Document type
články
články
Document record
Source: BMČ - články
Title
Flakka: New Dangerous Synthetic Cathinone on the Drug Scene / J. Patocka, B. Zhao, W. Wu, B. Klimova, M. Valis, E. Nepovimova, K. Kuca
Author
Patocka, Jiri
Department of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia, 37005 Ceske Budejovice, Czech Republic
Biomedical Research Centre, University Hospital, 50003 Hradec Kralove, Czech Republic

Zhao, Bingshu
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Wu, Wenda
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic

Klimova, Blanka
Department of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic

Valis, Martin
Department of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic

Nepovimova, Eugenie
Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic

Kuca, Kamil
Biomedical Research Centre, University Hospital, 50003 Hradec Kralove, Czech Republic
Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic

Cited source
International journal of molecular sciences. 2020, roč. 21, č. 21. ISSN: 1661-6596; 1422-0067 (elektronická verze).
Date of issue
2020
Language
angličtina
Country
Švýcarsko
Document type
články
DOI
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Pubmed ID
Link
Record number
bmc21011968
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English Abstract
New psychoactive substances are being used as drugs and appear to be quite popular nowadays. Thanks to their specific properties, these drugs create inimitable experiences for intoxicated people. Synthetic cathinones are the most common compounds in these new drugs. Among them, α-pyrrolidopentadione (α-PVP), or "Flakka" (street name), is one of the most famous cathinone-designed drugs. Similar to other synthetic cathinone drugs, α-PVP can effectively inhibit norepinephrine and dopamine transmitters. The adverse reactions of α-PVP mainly include mania, tachycardia, and hallucinations. An increasing number of people are being admitted to emergency wards due to the consequences of their use. This work mainly summarizes the history, synthesis, pharmacology, toxicology, structure-activity relationship, metabolism, clinical process and health risks, poisoning and death, forensic toxicology, and legal status of α-PVP. We hope this review will help bring more attention to the exploration of this substance in order to raise awareness of its negative impacts on humans.
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